Volume 8 | Issue 7 |

 Abstract

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Whole world is fighting against single enemy, novel corona virus (nCoV) causing respiratory trouble, the disease originated from Wuhan of China at the end of 2019 (COVID-19) which is very much similar with the corona virus causing severe acute respiratory syndrome, the disease outbrocken in 2003 (SARS). That is why nCoV is also called SARS-CoV-2/2019-nCoV. Present world is exhausted under massive lockdown and becoming looser day by day. No specific treatment yet to be established except repositioning of some old drugs, though they possess risky side effects. At this juncture to overcome adverse side effects of such drugs, aiming to search naturally occuring candidates targetting to establish a treatment model and to combat the challenge. The traditional plants/spices of bitter taste from Indian origin like Azadirachta indica A. Juss. (Indian Lilac/Neem/Nimtree), Andrographis paniculata (Burm. f.) Nees (green chirata/Indian kalmegh), Momordica charantia L. (bitter gourd/bitter melon/Indian karela), Moringa oleifera Lam. (Tree of life/Miracle-/Drumstick-/Horseradish tree), Curcuma longa L. (turmeric/Indian Haridra) rhizome and Nigella sativa L. (Black Cumin/Kalonji/Indian Kalojeera) seeds commonly pose the antimalarial, antidiabetic, antihyperlipidemic, anti-inflammatory/antiarthritic, immunomodulatory, and antiviral bioactive behaviors as therapeutics. Chloroquine/Hydroxychloroquine are resembled the same behaviors concomitantly. Both chloroquine(CQ) and hydroxychloroquine(HCQ) are synthetic antimalarial and antiarthritic drugs but recently repurposing the antiviral activity against SARS-CoV-2. CQ exhibits adverse side effects like vision loss, psychiatric disorder, cramp etc.. But HCQ, hydroxylated derivative of CQ is less toxic than CQ. HCQ on the other hand, it has been linked to some instances of cardiac arrhythmia, macular disorder and liver damage. Present study aiming to evaluate naturally occuring preventive/prophylactic/alternative potentials from Indian perspective searching database from existing literature and internets to overcome such odd side effects of CQ/HCQ on human subjects. The common/signature bioactive behaviors of some Indian traditional bitter plants/spices (SITBP/S) mentioned above and CQ/HCQ are more or less are found to be similar. Moreover SITBP/S exhibits anthelmintic and antiulcer good effects found from literature. Also a di-/tri-/polyherbal formulation could be suggested by constructing a Common base-tetra-triangular (CBTT) model for traditional treatment thus proposed and implimented on a very small group of COVID-19 suspected symptomatic patients from my Instititute at preliminary level, especially as preventive/prophylactic or alternative antiviral approach to SARS-CoV-2, might be rationalized to replace the CQ/HCQ side effective treatment. CBTT model of treatment + azithromycin (AZ) were implimented in presence or absence of antiallergic medications (AAMs) in symptomatic patients those who were denied to go Hospital. Without the AAMs, 7 days delay of recovery was observed. Resulting CBTT model +AZ + AAMs could be repurposed for faster recovery.

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COVID-19, CQ/HCQ: reposition and side effects, reposition of other drugs, SITBP/S and CBTT treatment model

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Reconstruction of the stright line is a very tedious task , given a noisy set of points in a 2D plane. In the reconstruction of the stright line there are several previous studies, all the studies reconstructing only uniform samples. Here implementation of a new approach to strightline reconstruction from noisy pointset. Choosing neighbor hood points and information regarding local density. Solving the surface issue from point sets make extensive use of the fact that the data are grouped into boundaries and the contours are situated in parallel planes. Similarly, specialist algorithms to rebuild surfaces From multiple viewpoint data range may leverage the data points adjacent connection within each. Implementing this reconstruction of stright lines by consistency and density informations.

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LFS, Noisy point sets

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Creative Commons Attribution 4.0 and The Open Definition

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Emily Dickinson�s poem captures various emotions related to life that she presents through her poem. Death is perceived as a life giving force in a different metaphysical sense of understanding. Spiritual crisis coupled with a sense of association with material reality forms a sense of conflict in her poems that she attempts to merge together to form a holistic meaning of life, reality and her worldview. In her worldview, death is treated as a being that helps to transcend the material reality and move towards achieving a sense of unity of being in spiritual sense.

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Romanticism, Transcendentalism, Puritan, Metaphysical, Ecstasy, Embodiment, Existentialist-Crisis.

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One of the most alarming issues of today�s world is exploitation and extinction. Everywhere there is scarcity of resources, unpredictable climatic variations, and unconducive atmosphere resulting in an unfriendly world. There is a drastic change in the natural and the human world due to human greed. Ruskin Bond�s short story �The Leopard� explores the cause of extinction and exploitation and throws light on the relationship between man and the other species. It also brings out the repercussions of misappropriation of natural resources.

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Extinction, Exploitation, Misappropriation, Unconducive

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We study the synthesis of Schiff's base ligand 2-Thiophenyl Ethanal Phenyl hydrazone 2-Carboxylic acid and their metal complexes of divalent Cobalt, Nickel, Copper, Zinc and Cadmium. Analytical study of metal salts were done by Half-integral method, Mid- point calculation method and straight line plot method. pH metric titration were carried out with the help of digital pH meter and stability constant of complexes of metal Co, Ni, Cu, Zn and Cd with ligand Synthesized were computed by Irving-Rossotti method modified by Calvin-Bjerrum. The stability constant values of given metal were found to be in the order Cu(II) >Ni(II) >Co(II) >Zn(II) >Cd(II). This result is in arrangement with the natural order proposed by Irving -William.

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Creative Commons Attribution 4.0 and The Open Definition

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An Aqua Silencer is used for control of emission and noise in automobile exhaust. By using activated charcoal, perforated tube and outer shell it is constructed. Or in other words Aqua Silencer is a modified version of a conventional silencer aimed at the reduction of toxic emission from the exhaust of an IC engine into the atmosphere and also to reduce the noise that is produced by damping methods which involves water and hence the name. Day by day the Air pollution is going on increasing. The main source of the pollution is Exhaust from automobiles and industries. Hence to reduce these pollutants from Exhaust of Engine a new technology is introduced called Aqua silencer. Decreasing the pollution level is now the main aim for many. Pollution is in many forms, almost every natural thing is now affected by the term pollution. Not only land, water, air, but each and every thing belongs to the planet is now in danger levels of pollution. Already human civilizations woke up to reduce this danger but are not into many things one of such is air. Air pollution is one of the hardest challenges to the humans as it is beyond our hand limits. So there must be a technology for that to decrease the alarming levels of air pollution. The discussed method also aims to bring the increased levels of pollution back to the bottom. In this method the air is being purified by the use of distilled water only, without the use of any synthetic material or chemical substance. Here, the air is made passed through the water so by reaction with water, pollutants stay in it results in clean air. In this method air is being purified by polluting water, but the fact is cleaning water is easy and there are many methods for this but cleaning air needs some boost up in the technology level. An Aqua silencer is a device used to filter the pollutants produced from automobiles such as CO2, CO3 etc., Due to water, the noise is also getting reduced than open environment. Because of this it gets named as AQUA SILENCER.

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Emission control, Air pollution, Internet of things, CO2 sensor, O2 sensor and Pic controller.

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Introduction: Acute disseminated encephalomyelitis (ADEM) is a demyelinating central nervous system disorder. The experience in children in our area is limited. Purpose: We describe a cohort of consecutive children with ADEM. Methods: Clinical and MRI of brain characteristics, treatment and outcome of a series of ADEM hospitalized in PICU, Oran University Hospital center (Algeria) from January 2011 to may 2016 were reviewed. Results: There were 07 males and 03 females. The mean age (median) at onset was 48 months [range, 6 �132 months]. All children had a prodromal event (infectious 08 cases or vaccination 02 cases). The mean interval between the febrile prodrome and the beginning of neurologic disturbance was 14 days (range, 3 to 30 days). Limb weakness (02 cases), ataxia (02 cases), ophtalmoplegia (02 cases) and acute hemiparesis (02 cases) were the most prominent initial findings. Aphasia was noticed in one patient. Seizure was observed in 07 patients. Consciousness disturbance (n=5) evolved into coma with cardiomyopathy of stress in one patient. CSF lymphocyte pleocytosis was found in 3 patients (9 � 208 cells/mm3). Initial MRI showed a deep gray matter involvement in 6 cases. Electroencephalogram (EEG) showed slowing of background activity in 04 patients. 05 patients were treating with IV immunoglobulin alone and 03 with high-dose IV methylprednisolone pulse. Among 10 patients, five had long-term neurological squeals. Conclusion: We conclude that early diagnosis and prompt treatment of ADEM will probably reduce morbidity and the seizures are not uncommon in ADEM.

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Encephalopathy, ADEM, Brain Magnetic Resonance Imaging, Children, Outcome

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Working capital plays the same role in a business concern as the role of the heart in a human body. If it is carried out effectively, efficiently and consistently, that will assure the financial health of an organization. In this study, the data of five top companies which is taken in Indian Retail Industries between the years 2014-2019, has been used. Return on Assets (ROA) has been used as indicators of company�s profitability and account receivable days, account payables days and inventory turnover days have been used as independent variables. Multiple regression, correlation methods, t-test and Altman Z score model have been used in empirical analysis. The result of analysis indicates that the ROA has positive significant relationship with ARD and negative significant with APD while ROA has negative insignificant relationship with ITD. The present study explores the impact of working capital management on the profitability of Indian Retail industry and its analysis the financial health during the study period. The study brings out a meaningful conclusion based on the findings of the study.

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Retail Industry, ROA, ARD, APD, ITD, Altman Z score model

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The Coronavirus pandemic and therefore the ensuing lockdown have forced schools and colleges across India to temporarily shut and this unprecedented move had created an enormous gap within the education bodies despite the central and government doing their best to support for e-learning and online education. Globally, the Indian Education sector is amongst the largest, with an extensive network of more than 1.4 million schools and 993 Universities, 39931 Colleges, and 10725 Stand Alone Institutions listed on the AISHE web portal. As the Indian education system was mostly based on the offline system and classes. Most of the primary and secondary schooling sector was all based on offline education system has to opt the online classes for empowering the education and for the benefits of the students. Many schools within the country have switched to online classes due to the lockdown, but one in four students is unable to attach because they don�t have a laptop, desktop, or tablet, consistent with a survey by economic times[1].

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EDUCATION SYSTEM,COVID-19,STUDENTS

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Creative Commons Attribution 4.0 and The Open Definition