Volume 12 | Issue 3 |

 Abstract

The use of certain drugs during the pregnancy might pose a risk to the developing foetus, raising concerns about the potential adverse effects on the foetal development and maternal health. This abstract will provide an overview of the intolerant drugs during pregnancy, focusing on their pharmacological activities, mechanism of crossing the placental barrier, and associated risks. Drugs that cross the placenta can impact foetal development by affecting the organs and systems, which leads to the congenital abnormalities and many other complications. The main factors that might influence the passage of the drug to the foetus might be the size, molecular weight, ionisation, or its binding strength. Some common examples of the ''Intolerant Drugs'' are: Thalidomide, ACE Inhibitors, Warfarin, Tetracyclines, Retinoids, and Ribavirin. All of these drugs have been evident to show some severe birth defects like limb abnormalities, kidney functioning issues, heart defects, or sometimes it can be fatal. It's important to note that the assessment of drug safety during pregnancy is complex, and varies under different circumstances. Healthcare workers play a crucial role in the evaluation of the risks and benefits of medication use in each case, considering factors such as the specific drug, the trimester of pregnancy, the health status of the pregnant individual, and alternative treatment options. Henceforth, this Abstract emphasises on the importance of medical guidance and reducing the risks associated with drug exposure during the pregnancy.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Intolerant drugs, foetal development, placental barrier, abnormalities, drug exposure, drug safety, medical guidance.

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

This research investigates the early detection of faults in bearings at the inner and outer race using condition monitoring techniques. Bearings play a critical role in various mechanical systems, and early fault detection is essential for preventing catastrophic failures and minimizing downtime. The study aims to evaluate the effectiveness of condition monitoring methods in identifying faults in both inner and outer races of bearings. A comprehensive literature review is conducted to provide context and identify gaps in existing research. The methodology involves selecting appropriate bearing types and fault scenarios, designing an experimental setup, and employing various conditions monitoring techniques for data acquisition and processing. Data analysis is performed to identify fault signatures and assess the accuracy of fault detection. Results indicate the efficacy of condition monitoring techniques in detecting faults at both inner and outer races, with insights into factors influencing early fault detection. The findings contribute to enhancing bearing maintenance practices and provide valuable guidance for future research in the field of condition monitoring.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Bearings, Condition monitoring

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

INTRODUCTION: Diffuse Axonal Injury(DAI) is a severe form of Traumatic Brain Injury(TBI) characterized by widespread damage to axons. While conventional treatments aim to manage acute symptoms, there is limited focus on addressing residual neurological deficits in the long term. In Ayurveda, TBI corresponds to Shiro-marma Abhigata and one among the Nidana of Vata Vyadhi. MATERIALS AND METHOD: This case study was conducted on a 28-year-old female patient who met with a road traffic accident resulting in DAI and severe head injury four years earlier. Since the neurological deficits persisted, the patient underwent a 27-day Ayurvedic treatment which included internal medications and Panchakarma procedures. RESULTS: The functional Independence Measurement(FIM) tool was used for the assessment. The patient improved her cognitive function, motor skills, and emotional well-being throughout the treatment. The FMI score recorded at the baseline and the end of the treatment showed a remarkable difference of 23 units thus improving the patient's QOL. DISCUSSION AND CONCLUSION: Therapeutic procedures such as Mrudhni taila, Madhutailika Basti, and internal medications effectively manage such disabilities. This study highlights the potential of Ayurvedic medicine as an effective and safe integrative approach for palliative management of the residual symptoms due to DAI such as tremors, memory loss, imbalance, and weakness. Thus, personalized and holistic methods of Ayurveda offer a promising avenue for improving the quality of life in individuals with neurological impairments.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Shiroabhighata, Palliative care, Post Traumatic Care, Rehabilitation in Ayurveda, Case Report

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Twentieth century age witnessed disintegration in ethical, philosophical and religious values in the life of the West. The problems of alienation, fragmentation and anxiety infused the sense of lack of direction and disbelief in the existing values which were aggravated by the deadly World War. T. S. Eliot (1888-1965) as a creator of modern sensibility employs his intellectual bent of mind to give objective expression to the chaos and loss of identity in modern life. He is the watershed of modern literary movement especially in poetry. He employs fragmentation in his poetry to demonstrate the disintegration of the modern European society. He is not pessimistic in showing this, rather he puts across a road map to wriggle out of the painful psychological condition. The present paper traces the process that begins with psychological fragmentation of modern Europe which ends in hope of spiritual renewal and reintegration.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Fragmentation, alienation, anxiety, disbelief, reintegration, modern sensibility

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Dysfunctional uterine bleeding it includes menorrhagia, metrorrhagia, polymenorrhea, fibroids,The research approach adopted for this study is quantitative approach. The research design adopted for the study was descriptive design . The sample consist of 100 women aged 30-45 years selected at maternity hospital , Tirupathi . The knowledge was assessed by using self structured questionnaire . Booklet was given to the study participants on the same day. The result shows that 50% had inadequate knowledge and 35% had moderate knowledge and 15% had adequate knowledge. The calculated Standard deviation 14.50 mean value(47.31).The result clearly showed that women had lack of knowledge regarding dysfunctional uterine bleeding.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Assess ,knowledge, Dysfunctional uterine bleeding, women

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Excellent and broad bio-spectrum of amide derivatives has generated an attractive platform for synthetic chemists to introduce structural modification in its nucleus by conventional access to new approaches. A new sequences of various amide derivatives have been design and synthesized. The methodology is proficient and simple to perform, giving the desired amides with excellent yield. An innovative series of four derivatives of amide were synthesized by the condensation of different compound like acetanilide, aniline, sulphanilamide and urea with benzoyl chloride in presence of sodium hydroxide as a catalyst. The reactions steps and the purity of the products were crisscross by using Thin Layer Chromatography (TLC). The chemical structure of final compounds were characterized and inveterate by measuring their melting points, elemental analysis, IR and 1H-NMR. The in-vitro antibacterial activity is done by using disc diffusion methods. The compounds were confirmed at different concentration from 0.02-0.10mg/ml in order to plaid the percentage inhibition of compounds. From the result compounds A1 and A2 presented highly significant activity against gram positive bacteria in comparison to standard sulphanilamide. A preliminary study of antimicrobial activity was performed in which antibacterial activity was done in two strains of bacterial activity was done. The results showed that compounds A1 and A2 have significant antibacterial activity compared with standard drugs and the other tested compounds have moderate to good activity.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

amide, antibacterial activity, antimicrobial activity

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Abstract : Agriculture plays a dominant role in economic development through supplying food for the nation, generating opportunities of employment, and sharing of national GDP as well as providing raw materials for agro based industries. Being the most backward district in the state in terms of agricultural output Dakshin Dinajpur District need a special attention. Because, as compared to the neighbouring districts, Dakshin Dinajpur appears to be good in terms of crop productivity, but at the same time the district is lagging behind so far as the development of agriculture is concerned. The district is predominantly agro based and majority of the people are engaged in agriculture. But the small land holdings hampering the growth in agriculture and allied sectors. Also inadequate management system, low crop diversification, improper crop planning with inadequate irrigation and drainage systems has led to the stagnation in agricultural development. The extent of stagnation in agriculture also varies from one block to another. Thus a spatial analysis of each block was in need to know the exact causes of this agricultural backwardness.Bhatia's method has been used to find out the crop diversification of South Dinajpur. The district also plays an important role in production of commercial crops like jute and food crop production.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Crops concentration, Crops intensity, Crops Combination, Crops Diversification

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

The research approach used for the study was Quantitative approach and its Non-experimental study. The setting of the study was Government Maternity Hospital, Tirupathi and Non probability convenient sampling technique was adopted for selection of the sample In this study out of 100 primi-antenatal mothers. The overall knowledge level of 100 primi-antenatal mothers. Among the sample 8 (8%) had inadequate knowledge with mean 23.75 & SD 1.67, 70(70%) had moderate knowledge with mean 31.07 & SD 2.65, 22(22%) had adequate knowledge with mean 40.45 & 2.54.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Primi-antenatal mothers, Assess, Knowledge, Child birth preparedness

  License

Creative Commons Attribution 4.0 and The Open Definition

 Abstract

Phishing is one of the familiar attacks that detects users to access malicious content and gain their information. Gradient Boosting Classifier is the model we utilised in our suggested strategy to identify phishing websites based on aspects of URL significance. By extracting and comparing different characteristics between legitimate and phishing URLs, the suggested method uses gradient boosting classifier to identify phishing URLs.

Licence: creative commons attribution 4.0

  License

Creative Commons Attribution 4.0 and The Open Definition

 Keywords

Phishing, Attack , Malicious , Gradient Boosting Classifier , Strategy , URL , Legitimate , Characteristics , Detection

  License

Creative Commons Attribution 4.0 and The Open Definition