Volume 12 | Issue 12 |

 Abstract

The floating drug delivery system or hydrodynamically balanced systems are among the several approaches that have been made developed in order to increase the gastric transit time of drug. The microspheres are characteristically free flowing powders consisting of natural or synthetic polymers and ideally having a particle size less than 200?m. Microspheres incorporating a drug dispersed or dissolved throughout particle matrix have the potential for the controlled release of drug.1 Microspheres are one of the multiarticulate delivery system and are prepared to obtain controlled the drug release from the dosage form to improve bioavailability, reduces the adverse action and prolong the action of drug, reduce absorption difference in patients, reduce the dosing frequency and adverse effects during prolong treatment. It is needed to formulate in long-acting dosage form, reaching to effective biological site rapidly.2,3 Famotidine is H2 receptor antagonist which is used for ulcers thus by formulating it in the form of floating microspheres it will not only show targeted action but also shows sustainability and reduced dosing interval. Thus, by formulating it as a floating microsphere the targeted action can be achieved. Famotidine is formulated as floating microspheres by Solvent evaporation method is the preparation technique that is widely preferred for the preparation of controlled release microspheres. To prepare emulsion by adding the dispersed phase consisting of drug, polymer and appropriate dispersion agent in organic solvent to dispersion medium which is immiscible with the dispersed phase and Mini matrix forms are obtained by removing the solvent used at the dispersed phase from the droplets which are formed in the emulsion5, 6.The obtained microspheres of famotidine were subjected to various analytical techniques like Particle size analysis, SEM analysis, invitro dissolution studies and stability studies.

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 Keywords

Famotidine, Floating microspheres, Solvent evaporation technique, Stability Studies

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Empowerment of women is said to be a day dream unless there is proper opportunity for their education. A society can achieve holistic development only when education is equally accessible to both men and women. Higher Education helps the women not only in gaining knowledge but also enables her to earn a living. Money is a necessity in maintaining life and education helps in preserving life. An educated woman plays an important role in a family, dealing with both health care and financial support to the family. As primary caregivers, educated mothers said to have significant impact on children development, nurturing educated families that contribute to societal progress. The paper highlights how women's participation in academia not only enhances their personal growth but also encourages collective upliftment within communities. This study explores the critical role of women in higher education within Barak Valley region of Assam, their presence in academia which tend to reveal the link they have particularly in improving livelihood and social transformation in general.

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 Keywords

Women academia, higher education, Society, Barak Valley, Assam

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Creative Commons Attribution 4.0 and The Open Definition

 Abstract

This days more trained in herbalism and herbal cosmetic it well liked by people world wide. Hair is a simple structure light in weight and delicate part of body it easily go to damage condition. Nowdays, people put back use of herbal cosmetics rather than the chemical treatment. Herb gives better result to make damage and dandruff free hair. Thus, create a herbal antidandruff hair mask it's a good for hair and hair problems. Totally chemical free formulation gift with extreme outcome use of herbal antidandruff hair mask gives assistance to darken and strengthen hair also obstruct the frizzy and damage hair. It also eliminate debris and dandruff this mask prevent many hair problem such as itching, chronic scalp infection, premature greying, increase scalp health as well as recent damage of the hair. Applications of herbal hair mask raise the hair healthy, glossy, hydrate, bouncy, and nourish. Herbal antidandruff hair mass is very affordable to people who look for more natural and lighter hair care product rather than the chemical spa. In composition of the mask many ancient Ayurvedic herbs used which provide the various favourable advantages to hair.

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 Keywords

Antidandruff, healthy hair, herbal, glossy, hydrate, advantages, hair problems, dandruff.

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This paper presents a deep learning approach to detect and classify brain tumors using Convolutional Neural Networks (CNN). The study leverages brain MRI scans, a non-invasive imaging technique, to detect abnormalities in the brain, which may indicate the presence of a tumor. A CNN-based model is proposed to automatically classify brain images into categories such as glioma, meningioma, and no tumor. Experimental results demonstrate that the proposed CNN model achieves a high classification accuracy, outperforming traditional methods. This approach significantly reduces the need for manual analysis, providing faster and more reliable results for early diagnosis.

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Tumor,bizarre cells, Magnetic Resonance Image

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This paper demonstrates building a feature-packed content generator using the MERN stack, highlighting its interactivity, scalability, and potential for future enhancements like user login and third-party tools.

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MongoDB, Express, React, and Node.js, Node.js, Express, Tailwind css/ Tanstack query, Optional authentication, rich text editor, responsive design

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Abstract Indian societies particularly Kerala society was marked for the existence of a rigid caste system. People were bound together by the caste rules and violating it leads to caste ostracism. Brahmins of Kerala who were generally called by the name Namboodiris, were the strict followers of their caste rules and these rules pulled them behind in the society, with the introduction of English education. A group of young people emerged among from them to work for the community reforms and established Yogakshemasabha to impart the importance of English education and to gradually bring an upliftment in their life.

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Key words: Namboodiri, Yogakshemasabha, English Education, V T Bhattathirippad, Yuvajanasangham

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Biosimilars are officially approved versions of original biopharmaceutical products whose patents have expired. The first generation of biopharmaceutical products, developed using recombinant technologies, was introduced in the 1980s and are now approaching patent expiration. Biologics are produced by cultured cells or whole organisms, which naturally results in more variability compared to chemical synthesis methods As a result, unlike generic pharmaceuticals, it is not possible to create an identical copy of an innovator product. Biosimilars are approved based on the same rigorous standards of pharmaceutical quality, safety, and efficacy that apply to all biological medicines. In the coming decades, biosimilar drugs are expected to surpass small molecule pharmaceuticals. The uptake of biosimilars is expected to keep growing as new blockbuster biological drugs continue to enter the pharmaceutical market. This review discusses the current trends and future prospects of biosimilars.

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Biosimilar, Biologics, Reference product, follow on biologics, Biopharmaceutical, Innovator biopharmaceutical product

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Fagonia Shweinfurthii Hadidi is a part of Zygophyllaceae family, has grabbed considerable attention due to its therapeutic potential. This review outlines the pharmacological activity, bioactive substances and possible therapeutic uses of Fagonia Shweinfurthii that can address many health issues. Fagonia is known for its various biological activities, such as anti-inflammatory, antioxidant, antimicrobial, antidiabetic and anticancer properties. Flavonoids, terpenoids and alkaloids are its main active ingredients and they play main role in its therapeutic effectiveness. Fagonia Shweinfurthii Hadidi has also shown protective action against liver harm, heart diseases and neurodegenerative disorders. Even though various researches are going on, the mechanism behind its therapeutic effects is not properly known, it will require additional studies on its pharmacokinetics, safety profiles and clinical efficacy. This review highlights the pharmacological potential of Fagonia Shweinfurthii Hadidi and also encourage its investigation as a source for new natural products aimed for the creation of future therapeutic approaches.

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Fagonia Shweinfurthii Hadidi, Dhamasa, Antioxidant Activity, Phytochemical, Anti-inflammatory

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This paper seeks to elucidate the concept of the centre and its broader implications. It critically examines the intricate architecture of the colonial education system and its pervasive impact on the current postcolonial global order. The analysis extends to the roles of culture and language in fostering the continuity and evolution of civilisations.

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Centrism, The Global South, Cultural identity, Christianity, Ngugi wa Thiong'o, Ethnicities, Neo-Colonialism

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The admissibility of electronic evidence in Indian courts has become a critical issue in the age of digital communication and technological advancement. With the increasing reliance on electronic records for both criminal and civil cases, the Indian legal framework, primarily governed by the Information Technology Act, 2000 and the Indian Evidence Act, 1872, has undergone significant reforms. Specifically, Section 65B of the Indian Evidence Act, inserted by the IT Act, 2000, establishes the conditions under which electronic records may be admissible as evidence in courts. However, despite these advancements, the application and interpretation of the legal provisions surrounding electronic evidence present numerous challenges. The paper explores the legal framework governing the admissibility of electronic records, examining both the requirements for the authenticity and reliability of digital evidence. The paper focuses on the procedural aspects of Section 65B, which mandates a certificate of authenticity from a responsible person involved in the creation or storage of the electronic record, but also highlights the complexities courts face in ensuring its compliance. It critically analyzes key judicial decisions, such as State (NCT of Delhi) v. Navjot Sandhu, which dealt with the admissibility of electronic evidence in the context of terrorism-related cases and established important precedents. The analysis further identifies challenges related to digital forensics, particularly in ensuring the integrity and preservation of electronic evidence, as well as issues regarding the chain of custody and the vulnerability of digital records to tampering or manipulation. Moreover, the paper delves into emerging challenges such as the admissibility of social media content, email evidence, and metadata in criminal and civil proceedings. Given the rapid evolution of technology, the legal framework in India must be continually updated to address new forms of digital evidence and prevent abuse or misuse. Finally, the paper provides recommendations for improving the admissibility standards and the overall judicial approach to electronic evidence in Indian courts.

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 Keywords

Electronic Evidence, Admissibility, Indian Evidence Act, Section 65B, Digital Forensics

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Creative Commons Attribution 4.0 and The Open Definition